ethyl P-methyl-2-nitro-5-chlorophenylphosphinate → ethyl P-methyl-2-amino-5-chlorophenylphosphinate
Reaction equation
[CH3:1][P:2]([C:7]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:8]=1[N+:14]([O-])=O)(=[O:6])[O:3][CH2:4][CH3:5]>CO.[Pd]>[CH3:1][P:2]([C:7]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:8]=1[NH2:14])(=[O:6])[O:3][CH2:4][CH3:5]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
Ethyl P-methyl-2-nitro-5-chlorophenylphosphinate (1.7 g, 7.5 mmol) dissolved in methanol (25 ml) is added to 200 mg of 5% palladium on carbon. The mixture is hydrogenated at 32 psi for 1 hour. The catalyst is then filtered off and the filtrate is evaporated to dryness to give ethyl P-methyl-2-amino-5-chlorophenylphosphinate.
Workup
- filtrationThe catalyst is then filtered off
- customthe filtrate is evaporated to dryness
Sources & evidence
- ORD record
- ord-0f90b9e8e3224c6c9f66c15bc4a19f4a
- Source dataset
- uspto-grants-1985_05
- Patent number
- US04520197
Reaction notes
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