2,4,5-Trifluorobenzenesulfonyl chloride → tert-Butyl 1,3-thiazol-4-yl[(2,4,5-trifluorophenyl)sulfonyl]carbamate

HRID 46375

Reaction equation

HRID 46375 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[S:10](Cl)(=[O:12])=[O:11].[C:14]([O:18][C:19](=[O:26])[NH:20][C:21]1[N:22]=[CH:23][S:24][CH:25]=1)([CH3:17])([CH3:16])[CH3:15]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[S:10]([N:20]([C:21]1[N:22]=[CH:23][S:24][CH:25]=1)[C:19](=[O:26])[O:18][C:14]([CH3:17])([CH3:15])[CH3:16])(=[O:12])=[O:11]

Participants

3

Reactant 2

HCID 27769792,4,5-Trifluorobenzenesulfonyl chlorideHCID 53241636tert-butyl N-(1,3-thiazol-4-yl)carbamate

Product 1

HCID 59436528tert-Butyl 1,3-thiazol-4-yl[(2,4,5-trifluorophenyl)sulfonyl]carbamate

Procedure

The above titled compound was prepared from 2,4,5-trifluorobenzenesulfonyl chloride (5.0 g, 0.022 mol) and thiazole-4-yl-carbamic acid tert-butyl ester (Preparation 72, 4.3 g, 0.022 mol) using the method of Preparation 453 to afford the product as a white solid (6.84 g, 80%).

Sources & evidence

ORD record
ord-9761d7d53afa453cb43ddbba5f9cc9ec
Source dataset
uspto-grants-2013_09
Patent number
US08541588B2

Linked notes

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