Ethanolamine → Phenylglycine nitrile

HRID 463812

Reaction equation

HRID 463812 reaction equation
[C:1]([CH2:3][C:4]12[CH:20]=[CH:19][CH:18]=[CH:17][CH:5]1C(N(C1C=CC=CC=1)C2=O)=O)#[N:2].C(C[NH2:24])O>>[NH2:24][C:5]1[CH:17]=[CH:18][CH:19]=[CH:20][C:4]=1[CH2:3][C:1]#[N:2]

Participants

3

Reactant 2

HCID 700EthanolamineHCID 20265457HCID 20265457, compound

Product 1

HCID 76307Phenylglycine nitrile

Conditions

Temperature
20 °C

Procedure

100 g of 2-cyanomethyl-N-phenylphthalimide were introduced, a little at a time, into 100 g of monoethanolamine at 80° C. After 10 minutes, the mixture was cooled to 20° C., and 400 g of ice water were added dropwise. The precipitated product was filtered off under suction and washed neutral with ice water.

Workup

  1. customat 80° C
  2. filtrationThe precipitated product was filtered off under suction
  3. washwashed neutral with ice water

Sources & evidence

ORD record
ord-7c7b2faa11fd4a8da8c7465902762202
Source dataset
uspto-grants-1985_10
Patent number
US04544755

Linked notes

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