2-Amino-5-bromo-1,3,4-thiadiazole → N-[3-[3-(1-Pyrrolidinylmethyl)phenoxy]propyl]-1,3,4-thiadiazole-2,5-diamine

HRID 4640

Reaction equation

HRID 4640 reaction equation
[N:1]1([CH2:6][C:7]2[CH:8]=[C:9]([CH:15]=[CH:16][CH:17]=2)[O:10][CH2:11][CH2:12][CH2:13][NH2:14])[CH2:5][CH2:4][CH2:3][CH2:2]1.Br[C:19]1[S:23][C:22]([NH2:24])=[N:21][N:20]=1>>[N:1]1([CH2:6][C:7]2[CH:8]=[C:9]([CH:15]=[CH:16][CH:17]=2)[O:10][CH2:11][CH2:12][CH2:13][NH:14][C:19]2[S:23][C:22]([NH2:24])=[N:21][N:20]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 36508832-Amino-5-bromo-1,3,4-thiadiazoleHCID 127974543-{3-[(Pyrrolidin-1-yl)methyl]phenoxy}propan-1-amine

Product 1

HCID 20142405N-[3-[3-(1-Pyrrolidinylmethyl)phenoxy]propyl]-1,3,4-thiadiazole-2,5-diamine

Procedure

The compound is prepared by a method analogous to that of Example 51 from 3-[3-(1-pyrrolidinylmethyl)-phenoxy]1-propanamine and 5-bromo-1,3,4-thiadiazole-2-amine.

Sources & evidence

ORD record
ord-aba52494f2a54ca8be4f2454e2d88a82
Source dataset
uspto-grants-1988_02
Patent number
US04727081

Linked notes

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