HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 4648Generated: October 26, 2026
3-Hydroxybenzaldehyde → 3-[(3-Methylpiperidin-1-yl)methyl]phenol
https://huagongshe.com/reaction/4648
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Hydroxybenzaldehyde | HCID 101 | — |
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | 3-Methylpiperidine | HCID 79081 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-[(3-Methylpiperidin-1-yl)methyl]phenol | HCID 13364666 | — |
Reaction Steps
24.4 g (0.2 mol) of 3-hydroxybenzaldehyde are mixed with 40 ml (about 0.4 mol) of 3-methylpiperidine and 20 ml (about 0.52 mol) of 100% formic acid with cooling and then stirred for 2 hours at 120° C. When the reaction mixture has cooled to room temperature, it is poured into water and rendered alkaline with ammonia, and the precipitated solid is filtered off and recrystallised from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04727081 |
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| Source dataset | uspto-grants-1988_02 |
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| ORD ID | ord-e9c53b21b5524c4296badbb52530d5b3 |
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| Source note | uspto-grants-1988_02 |
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