HCID 20387356, compound → 2-(1,2,3,4,5,8-Hexahydro-3-hydroxynaphthalenyl)-1-methylpyrrolidine

Reaction equation

[OH:1][CH:2]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]([CH:12]2[CH2:16][CH2:15][CH2:14][N:13]2[CH3:17])[CH2:3]1.OC1C(O)C2C(=CC=CC=2)CC1C1CCN(C)C1>>[OH:1][CH:2]1[CH2:11][C:10]2[CH2:9][CH:8]=[CH:7][CH2:6][C:5]=2[CH:4]([CH:12]2[CH2:16][CH2:15][CH2:14][N:13]2[CH3:17])[CH2:3]1

Participants

Reactant 2

HCID 20387356HCID 20387356, compound

HCID 203873713-(3,4-Dihydroxy-1,2,3,4-tetrahydro-2-naphthalenyl)-1-methylpyrrolidine

Product 1

HCID 203873722-(1,2,3,4,5,8-Hexahydro-3-hydroxynaphthalenyl)-1-methylpyrrolidine

Procedure

Following the procedure of Example 6, part D, but substituting the 2-(3-hydroxy-1,2,3,4-tetrahydronaphthalenyl)-1-methylpyrrolidine for the 3-(3,4-dihydroxy-1,2,3,4-tetrahydro-2-naphthalenyl)-1-methylpyrrolidine, the title C compound is obtained.

Workup

customthe title C compound is obtained

Sources & evidence

ORD record: ord-3f431dcca6a643e28ef683d9f6003b94
Source dataset: uspto-grants-1979_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04173640

Reaction notes

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