2-Amino-5-bromo-1,3,4-thiadiazole → N-[4 [3-((3-Methylpiperidin-1-yl)methyl)phenoxy]butyl]1,3,4-thiadiazole-2,5-diamine

HRID 4651

Reaction equation

HRID 4651 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][N:4]([CH2:8][C:9]2[CH:10]=[C:11]([CH:18]=[CH:19][CH:20]=2)[O:12][CH2:13][CH2:14][CH2:15][CH2:16][NH2:17])[CH2:3]1.Br[C:22]1[S:26][C:25]([NH2:27])=[N:24][N:23]=1>>[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][N:4]([CH2:8][C:9]2[CH:10]=[C:11]([CH:18]=[CH:19][CH:20]=2)[O:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][C:22]2[S:26][C:25]([NH2:27])=[N:24][N:23]=2)[CH2:3]1

Participants

3

Reactant 2

HCID 36508832-Amino-5-bromo-1,3,4-thiadiazoleHCID 140261874-[3-[(3-Methylpiperidin-1-yl)methyl]phenoxy]butanamine

Product 1

HCID 20151485N-[4 [3-((3-Methylpiperidin-1-yl)methyl)phenoxy]butyl]1,3,4-thiadiazole-2,5-diamineYield 54%

Procedure

The compound is prepared by a method analogous to that of Example 51 from 4-[3-[(3-methylpiperidin-1-yl) methyl]phenoxy]-butanamine and 5-bromo-1,3,4-thiadiazole2-amine. Yield: 54% of theoretical: melting point: 123°-124° C.

Sources & evidence

ORD record
ord-eb4404a529524bbaaeb145c12af0db55
Source dataset
uspto-grants-1988_02
Patent number
US04727081

Linked notes

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