2-Amino-5-bromo-1,3,4-thiadiazole → N-[3-[3-((3-Methylpyrrolidin-1-yl)methyl)phenoxy]propyl]1,3,4-thiadiazole-2,5-diamine

HRID 4653

Reaction equation

HRID 4653 reaction equation
[CH3:1][CH:2]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]2[CH:9]=[C:10]([CH:16]=[CH:17][CH:18]=2)[O:11][CH2:12][CH2:13][CH2:14][NH2:15])[CH2:3]1.Br[C:20]1[S:24][C:23]([NH2:25])=[N:22][N:21]=1>>[CH3:1][CH:2]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]2[CH:9]=[C:10]([CH:16]=[CH:17][CH:18]=2)[O:11][CH2:12][CH2:13][CH2:14][NH:15][C:20]2[S:24][C:23]([NH2:25])=[N:22][N:21]=2)[CH2:3]1

Participants

3

Reactant 2

HCID 36508832-Amino-5-bromo-1,3,4-thiadiazoleHCID 140261893-[3-[(3-Methylpyrrolidin-1-yl) methyl]phenoxy]propanamine

Product 1

HCID 20151479N-[3-[3-((3-Methylpyrrolidin-1-yl)methyl)phenoxy]propyl]1,3,4-thiadiazole-2,5-diamine

Procedure

The compound is prepared by a method analogous to that of Example 51 from 3-[3-[(3-methylpyrrolidin-1-yl) methyl]phenoxy]propanamine and 5-bromo-1,3,4-thiadiazole-2-amine.

Sources & evidence

ORD record
ord-0006ecc213bc472e9ba0b4816a5ec055
Source dataset
uspto-grants-1988_02
Patent number
US04727081

Linked notes

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