Acetic Anhydride → 2-(p-Fluorobenzoyl)-3-methoxy-2-pentenonitrile

Participants

Reaction Steps

A solution containing 30 g. of (p-fluorobenzoyl)acetonitrile, 36.4 g. of trimethylorthopropionate and 57 g. of acetic anhydride is heated in an oil bath at 130° for 3 hours. The ethanol and excess acetic anhydride is distilled off and the residue is diluted with chloroform. The chloroform solution is passed quickly through Magnesol® and concentrated, then cooled to produce the title product.

Provenance & Evidence