Methyl 2-chloroacrylate → 5-Chloro-5-methoxycarbonyl-3-thiapentanamide
Reaction equation
[SH:1][CH2:2][C:3]([NH2:5])=[O:4].O1CCOCC1.[Cl:12][C:13](=[CH2:18])[C:14]([O:16][CH3:17])=[O:15]>N1C=CC=CC=1>[Cl:12][CH:13]([C:14]([O:16][CH3:17])=[O:15])[CH2:18][S:1][CH2:2][C:3]([NH2:5])=[O:4]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
2-Mercaptoacetamide (18.79 g) was stirred in a mixture of dry 1,4-dioxan (200 ml) and dry pyridine (33.5 ml)) whilst methyl 2-chloroacrylate (24.88 g) was added dropwise over 15 minutes. The mixture was stirred for 1 hour then stood overnight. The resultant mixture contained the title compound.
Workup
- additionwas added dropwise over 15 minutes
- waitthen stood overnight
Sources & evidence
- ORD record
- ord-7ee7a85c10d545b4b1ed1df425ca1296
- Source dataset
- uspto-grants-1992_10
- Patent number
- US05153330
Reaction notes
Loading…