Benzoyl chloride → 4-Benzoyloxy-2-pyridone
Reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][NH:5][C:4](=[O:8])[CH:3]=1.[C:9](Cl)(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>N1C=CC=CC=1>[C:9]([O:1][C:2]1[CH:7]=[CH:6][NH:5][C:4](=[O:8])[CH:3]=1)(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
50 ml of a solution of 1.00 g of 4-hydroxy-2-pyridone and 1.35 ml of benzoyl chloride in pyridine was refluxed for 6 hours. After the pyridine was distilled off, the residue was mixed with water. The precipitate was recovered by filtration and was washed with a small amount of ethanol to obtain 0.86 g of the title compound in a yield of 44%.
Workup
- distillationAfter the pyridine was distilled off
- additionthe residue was mixed with water
- filtrationThe precipitate was recovered by filtration
- washwas washed with a small amount of ethanol
Sources & evidence
- ORD record
- ord-ff2759b4c10a440087bdb0d6c4f019b1
- Source dataset
- uspto-grants-1992_10
- Patent number
- US05155113
Reaction notes
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