Acetic Acid → 1H-Imidazo[4,5-b]pyridine,2,7-dimethyl-(9CI)

HRID 466693

Reaction equation

HRID 466693 reaction equation
[NH2:1][C:2]1[C:7]([NH2:8])=[C:6]([CH3:9])[CH:5]=[CH:4][N:3]=1.[C:10](O)(=O)[CH3:11]>>[CH3:10][C:11]1[NH:8][C:7]2[C:2]([N:1]=1)=[N:3][CH:4]=[CH:5][C:6]=2[CH3:9]

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 3174954-Methylpyridine-2,3-diamine

Product 1

HCID 223885531H-Imidazo[4,5-b]pyridine,2,7-dimethyl-(9CI)

Procedure

The title compound was prepared from 2,3-diamino-4-picoline (0.246 g, 2 mmol) and acetic acid (0.15 ml) according to the procedure described in Step 1 of Example 9. The crude product was purified by flash chromatography on silica-gel using EtOAc-MeOH (9:1) to give the pure product (0.25 g, 85%) as a light brown solid.

Workup

  1. customThe crude product was purified by flash chromatography on silica-gel

Sources & evidence

ORD record
ord-26cedda587d24dfca7f9eca11b9d524b
Source dataset
uspto-grants-1992_10
Patent number
US05157026

Linked notes

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