Chloromethyl pivalate → Ticlopidine Hydrochloride
Reaction equation
[C:1](OC[Cl:9])(=O)C(C)(C)C.[Cl:10][C:11]1[CH:25]=[CH:24][CH:23]=[CH:22][C:12]=1[CH2:13][NH:14][CH2:15][CH2:16][C:17]1[S:18][CH:19]=[CH:20][CH:21]=1>CS(C)=O>[ClH:9].[Cl:10][C:11]1[CH:25]=[CH:24][CH:23]=[CH:22][C:12]=1[CH2:13][N:14]1[CH2:15][CH2:16][C:17]2[S:18][CH:19]=[CH:20][C:21]=2[CH2:1]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
66.5 g (0.44 M) chloromethyl pivalate is reacted by heating, for 3 hours, with a solution of 103 g (0.4 M) N-(2-chloro-benzyl)-2-(2-thienyl)ethylamine in 300 ml dimethylsulfoxide, to give the title compound in a yield of 51%.
Sources & evidence
- ORD record
- ord-e1e3cd2e741d47f5826cb8f92d901749
- Source dataset
- uspto-grants-1979_11
- Patent number
- US04174448
Reaction notes
Loading…