Cyanogen Bromide → 1-(4-bromo-2-butynyl)-1,3-dihydro-3-methyl-2H-imidazol-2-one
Reaction equation
N#[C:2][Br:3].C(N(CC)C[C:8]#[C:9][CH2:10][N:11]1[CH:15]=[CH:14][N:13]([CH3:16])[C:12]1=[O:17])C>O1CCOCC1>[Br:3][CH2:2][C:8]#[C:9][CH2:10][N:11]1[CH:15]=[CH:14][N:13]([CH3:16])[C:12]1=[O:17]Participants
4
Procedure
Cyanogen bromide (6.0 g, 0.057 mol) was added to a stirred solution of 1-[4-(diethylamino)-2-butynyl]-1,3-dihydro-3-methyl-2H-imidazol-2-one in dioxane (130 mL). After evaporation of the dioxane, the residual oil was chromatographed on silica gel using chloroform: 1% methanol as the eluant to give 10.8 g of 1-(4-bromo-2-butynyl)-1,3-dihydro-3-methyl-2H-imidazol-2-one as an oil.
Workup
- customAfter evaporation of the dioxane
- customthe residual oil was chromatographed on silica gel
Sources & evidence
- ORD record
- ord-62fed6f1826f473d8637b3a2f0e51fc7
- Source dataset
- uspto-grants-1992_10
- Patent number
- US05157124
Reaction notes
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