Butylamine → N-Butyl-N'-methylurea
Reaction equation
[CH2:1]([NH2:5])[CH2:2][CH2:3][CH3:4].[CH3:6][N:7]=[C:8]=[O:9]>ClCCl>[CH3:6][NH:7][C:8]([NH:5][CH2:1][CH2:2][CH2:3][CH3:4])=[O:9]Participants
4
Reagents, catalysts & solvents 1
Procedure
280.32 Grams (3.84 moles) of butylamine and 300 ml of dichloromethane were charged to a round bottom flask equipped with stirrer, cold bath, thermometer, addition funnel and reflux condenser. 229.8 Grams (4.03 Moles, a 5% excess) of methyl isocyanate were charged to the addition funnel and added to the flask contents over four hours keeping the contents between 0° and 35° C. After an additional hour of stirring the exothermic reaction subsided and the mixture was allowed to stand overnight.
Workup
- customequipped with stirrer, cold bath
- additionthermometer, addition funnel
- temperaturereflux condenser
- additionadded to the flask contents over four hours
- customthe contents between 0° and 35° C
- customthe exothermic reaction
Sources & evidence
- ORD record
- ord-deac1033c0304fbba96c1259253febb4
- Source dataset
- uspto-grants-1992_10
- Patent number
- US05158808
Reaction notes
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