4-Benzyloxy-3-methoxyphenylacetyl chloride → N-(4-benzyloxy-3-methoxyphenylacetyl)-4-aminomethyl-2H-1-benzopyran

HRID 467041

Reaction equation

HRID 467041 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16](Cl)=[O:17])=[CH:11][C:10]=1[O:19][CH3:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:21][CH2:22][C:23]1[C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=2[O:26][CH2:25][CH:24]=1>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([NH:21][CH2:22][C:23]2[C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=3[O:26][CH2:25][CH:24]=2)=[O:17])=[CH:11][C:10]=1[O:19][CH3:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 110982704-Benzyloxy-3-methoxyphenylacetyl chlorideHCID 129148694-aminomethyl-2H-1-benzopyran

Product 1

HCID 19813061N-(4-benzyloxy-3-methoxyphenylacetyl)-4-aminomethyl-2H-1-benzopyran

Procedure

4-Benzyloxy-3-methoxyphenylacetyl chloride, prepared as described in Example 4, and 4-aminomethyl-2H-1-benzopyran, prepared as described in Step 1 of Example 136, were condensed as described in Step 1 of Example 6 to give the lactam, N-(4-benzyloxy-3-methoxyphenylacetyl)-4-aminomethyl-2H-1-benzopyran.

Workup

  1. customprepared
  2. customcondensed

Sources & evidence

ORD record
ord-239b43d880d14c95a0f7677dddbe6a70
Source dataset
uspto-grants-1992_10
Patent number
US05158948

Linked notes

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