Ethyl isocyanoacetate → Ethyl 3-ethyl-4-methyl-1H-pyrrole-2-carboxylate

Reaction equation

C(O[CH:5]([CH2:11][CH3:12])[CH:6]([N+]([O-])=O)[CH3:7])(=O)C.[N+:13]([CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])#[C-:14]>>[CH2:11]([C:5]1[C:6]([CH3:7])=[CH:14][NH:13][C:15]=1[C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH3:12]

Participants

Reactant 2

HCID 533707Ethyl isocyanoacetate

HCID 11805252HCID 11805252, compound

Product 1

HCID 11789832Ethyl 3-ethyl-4-methyl-1H-pyrrole-2-carboxylate

Procedure

reacting 3-acetoxy-2-nitropentane with ethyl isocyanoacetate in the presence of a nonnucleophilic base to form ethyl 3-ethyl-4-methylpyrrole-2-carboxylate;

Sources & evidence

ORD record: ord-8d2f00bef515466fa818efcab4a0653c
Source dataset: uspto-grants-1992_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05159065

Reaction notes

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