1,2-Diaminocyclohexane → trans-Bis(methylammine)dichloroplatinum(II)

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Reaction Steps

Dichloro (1,2-diaminocyclohexane)platinum (II) was synthesized as described by Gale et al, Research Communications in Chemical Pathology and Pharmacology, Volume 7, No. 3, Pages 529-538, March 1974. Thus, Potassium tetrachloroplatinite, K2Pt Cl4 (20 mM) in 75 ml water was mixed with 1,2-diaminocyclohexane (20 mM) for three hours at room temperature. The insoluble product was removed by filtration, washed with water and then with methanol, and oven-dried. The yield was approximately 90% of theory. The product was then purified by dissolution in dimethylformamide, filtration, and addition of three volumes of methanol or 0.1 N HCl. This product was filtered, washed, and dried as above. The yield in purification was 47%.

Provenance & Evidence