HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofurfurylamine → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid {4-[(tetrahydro-furan-2-ylmethyl)-carbamoyl]-pyridin-3-yl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofurfurylamine | HCID 253298 | — |
| Reactant | 3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid | HCID 70098928 | — |
| Product | 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carboxylic acid {4-[(tetrahydro-furan-2-ylmethyl)-carbamoyl]-pyridin-3-yl}-amide | HCID 58548374 | 77% |
Reaction Steps
According to the procedure described in step 3 of example 99, 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid (example 99, step 2) was reacted with (tetrahydrofuran-2-yl)methanamine, providing the title compound as yellow solid (77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08623866B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-f942ca0cd54a435bbd04ab545989cbff |
| Source note | uspto-grants-2014_01 |