Thionyl Chloride → 3-Bromo-4-fluorobenzoyl chloride

HRID 469332Notes

Reaction equation

HRID 469332 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5](O)=[O:6].S(Cl)([Cl:14])=O>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5]([Cl:14])=[O:6]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 705093-Bromo-4-fluorobenzoic acid

Product 1

HCID 695983-Bromo-4-fluorobenzoyl chloride

Procedure

2.17 g (9.41 mmol) 3-bromo-4-fluorobenzoic acid were mixed with 20 mL thionyl chloride and then boiled for 2 h. The reaction mixture was evaporated to dryness and coevaporated twice with toluene. The residue was reacted further as the crude product.

Workup

  1. customThe reaction mixture was evaporated to dryness
  2. customThe residue was reacted further as the crude product

Sources & evidence

ORD record
ord-b8ace32349b54da58a96b7c11a9daa56
Source dataset
uspto-grants-2014_01
Patent number
US08629137B2

Reaction notes

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