Thionyl Chloride → 3,5-Difluorobenzoyl chloride

HRID 469337

Reaction equation

HRID 469337 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([F:11])[CH:10]=1)[C:5](O)=[O:6].S(Cl)([Cl:14])=O>>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([F:11])[CH:10]=1)[C:5]([Cl:14])=[O:6]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 1012653,5-Difluorobenzoic acid

Product 1

HCID 1456003,5-Difluorobenzoyl chloride

Procedure

1.63 g (10.00 mmol) 3,5-difluoro-benzoic acid were mixed with 20 mL thionyl chloride and boiled for 2 h. The reaction mixture was evaporated to dryness and coevaporated twice with toluene. The residue was reacted further as the crude product.

Workup

  1. customThe reaction mixture was evaporated to dryness
  2. customThe residue was reacted further as the crude product

Sources & evidence

ORD record
ord-a565cd0d833a42f3b36e645c6b592ea7
Source dataset
uspto-grants-2014_01
Patent number
US08629137B2

Linked notes

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