Thionyl Chloride → 3-Cyano-5-fluoro-benzoic acid chloride
Reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([F:12])[CH:11]=1)[C:6](O)=[O:7])#[N:2].S(Cl)([Cl:15])=O>>[C:1]([C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([F:12])[CH:11]=1)[C:6]([Cl:15])=[O:7])#[N:2]Participants
3
Procedure
1.65 g (10.0 mmol) 3-cyano-5-fluorobenzoic acid were boiled for 2 h with 7.27 mL (100 mmol) thionyl chloride with stirring. The reaction mixture was evaporated to dryness i. vac. and coevaporated twice with toluene. The residue was reacted further as the crude product.
Workup
- customThe reaction mixture was evaporated to dryness i
- customThe residue was reacted further as the crude product
Sources & evidence
- ORD record
- ord-283c3667309b4b41b7d6e7a741c75ffd
- Source dataset
- uspto-grants-2014_01
- Patent number
- US08629137B2
Reaction notes
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