4-Aminopyridazine → 5-cyclohexyl-N-pyridazin-4-yl-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

HRID 469793

Reaction equation

HRID 469793 reaction equation
[CH:1]1([C:7]2[C:8]([O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[N:9][CH:10]=[C:11]([CH:15]=2)[C:12]([OH:14])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[N:22]1[CH:27]=[CH:26][C:25]([NH2:28])=[CH:24][N:23]=1>>[CH:1]1([C:7]2[C:8]([O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[N:9][CH:10]=[C:11]([CH:15]=2)[C:12]([NH:28][C:25]2[CH:26]=[CH:27][N:22]=[N:23][CH:24]=2)=[O:14])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 2984924-AminopyridazineHCID 712939525-Cyclohexyl-6-(2,2,2-trifluoroethoxy)nicotinic acid

Product 1

HCID 712942985-cyclohexyl-N-pyridazin-4-yl-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

Procedure

This compound was prepared following the same procedure as described in Example 11 using 5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (Example 4b) (100 mg, 0.33 mmol) and 4-pyridazinamine (CAN 20744-39-2, 31.4 mg, 0.33 mmol) as starting materials; off white solid (60 mg, 47.8%). MS (ESI): 381.4 (M+H)+.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-63f01adf23b44b20887b196c114af723
Source dataset
uspto-grants-2014_01
Patent number
US08629166B2

Linked notes

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