HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 2-Amino-6-bromophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 2-Bromo-6-nitrophenol | HCID 13545453 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Amino-6-bromophenol | HCID 15531506 | — |
Reaction Steps
A solution of 5.3 g (22.7 mmol) 2-bromo-6-nitro-phenol in 100 ml MeOH:THF=1:1 is hydrogenated in the presence of 0.2 g Ra—Ni (in EtOH, Degussa B113W). The reaction mixture is filtered (2 glass fiber filters used) and the filtrate is concentrated in vacuo to afford the crude title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629168B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-26bd5e9dcb284bcea424992ae7e1b2c8 |
| Source note | uspto-grants-2014_01 |