Isopropyl iodide → 3-Isopropyl-1H-indol-6-amine
Reaction equation
[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([CH:8]=[CH:9][NH:10]2)=[CH:6][CH:5]=1)([O-])=O.[CH:13](I)([CH3:15])[CH3:14]>CC#N>[CH:13]([C:8]1[C:7]2[C:11](=[CH:12][C:4]([NH2:1])=[CH:5][CH:6]=2)[NH:10][CH:9]=1)([CH3:15])[CH3:14]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
3-Isopropyl-1H-indol-6-ylamine (B-13) was synthesized following the general scheme above starting from 6-nitroindole and isopropyl iodide. Overall yield (17%). HPLC ret. time 2.06 min, 10-99% CH3CN, 5 min run; ESI-MS 175.2 m/z (MH+).
Workup
- customOverall yield (17%)
Sources & evidence
- ORD record
- ord-5861a52d82d140acaab5c40edb58f4d2
- Source dataset
- uspto-grants-2014_01
- Patent number
- US08629162B2
Reaction notes
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