L-Proline → 6-methoxy-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione

HRID 4705

Reaction equation

HRID 4705 reaction equation
C[C:2]1[C:7]2[C:8](=[O:17])[N:9]3[CH2:16]CC[C@H:10]3[C:11](=[O:13])[NH:12][C:6]=2[CH:5]=[CH:4][CH:3]=1.N1CCC[C@H]1[C:20](O)=[O:21]>>[CH3:20][O:21][C:2]1[C:7]2[C:8](=[O:17])[N:9]([CH3:16])[CH2:10][C:11](=[O:13])[NH:12][C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 145742L-ProlineHCID 13891432(S)-1,2,3,11a-tetrahydro-6-methyl-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H)-dione

Product 1

HCID 212919776-methoxy-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione

Procedure

(S)-6-methyl-1,2,3,11a-tetrahydro-5H-pyrrolo (2,1-c) (1,4) benzodiazepine-5,11 (10H)-dione by reaction with L-proline. M.p. 207.6°-209.9° C.

Sources & evidence

ORD record
ord-5eae9c249c2f4d548c00c56de8b74d45
Source dataset
uspto-grants-1988_02
Patent number
US04727153

Linked notes

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