2,2,2-Trifluoroethyl trifluoromethanesulfonate → 4-iodo-1-(2,2,2-trifluoroethyl)pyridin-2(1H)-one

Reaction equation

[I:1][C:2]1[CH:7]=[CH:6][NH:5][C:4](=[O:8])[CH:3]=1.FC(F)(F)S(O[CH2:15][C:16]([F:19])([F:18])[F:17])(=O)=O>>[I:1][C:2]1[CH:7]=[CH:6][N:5]([CH2:15][C:16]([F:19])([F:18])[F:17])[C:4](=[O:8])[CH:3]=1

Participants

Reactant 2

HCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonate

HCID 205825354-Iodo-1,2-dihydropyridin-2-one

Product 1

HCID 667369834-iodo-1-(2,2,2-trifluoroethyl)pyridin-2(1H)-one

Procedure

4-iodo-1-(2,2,2-trifluoroethyl)pyridin-2(1H)-one was prepared from 4-iodopyridin-2(1H)-one and 2,2,2-trifluoroethyl trifluoromethanesulfonate following a procedure analogous to that described in Example 59 Step 1.

Sources & evidence

ORD record: ord-a6b0f3b9f0444710b199cbab08db504c
Source dataset: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08629138B2

Reaction notes

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