Acetic Acid → 3-[[(3,4-dimethoxyphenyl)methylamino]methylidene]-5,6-dimethoxy-1H-indol-2-one

HRID 47076

Reaction equation

HRID 47076 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[NH:8][C:7](=[O:14])[C:6]2=[CH:15]O.[CH3:17][O:18][C:19]1[CH:20]=[C:21]([CH:24]=[CH:25][C:26]=1[O:27][CH3:28])[CH2:22][NH2:23].C(O)(=O)C>C1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[NH:8][C:7](=[O:14])[C:6]2=[CH:15][NH:23][CH2:22][C:21]1[CH:24]=[CH:25][C:26]([O:27][CH3:28])=[C:19]([O:18][CH3:17])[CH:20]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 79832VeratrylamineHCID 178486553HCID 178486553, compound

Product 1

HCID 1784910763-[[(3,4-dimethoxyphenyl)methylamino]methylidene]-5,6-dimethoxy-1H-indol-2-one

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

5.00 g. of 5,6-Dimethoxy-3-hydroxymethylene oxindole, 6.00 g. of 3,4-dimethoxy benzylamine and 2.20 g. of acetic acid in 40 ml. benzene were reacted as described in Example 5 to give 5.44 g. of product, m.p. 198°-200° C.

Workup

  1. customto give 5.44 g

Sources & evidence

ORD record
ord-097da2f5504447ae984f864cc7fdd477
Source dataset
uspto-grants-1979_11
Patent number
US04176191

Linked notes

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