HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → 4,4-Dimethyl-7-(2,4-dimethoxybenzoyl amino)-8-nitro-2H,4H-isoquinoline-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | 2,4-Dimethoxybenzoyl chloride | HCID 2734719 | — |
| Reactant | 1,3(2H,4H)-Isoquinolinedione, 7-amino-4,4-dimethyl-8-nitro- | HCID 11118443 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 4,4-Dimethyl-7-(2,4-dimethoxybenzoyl amino)-8-nitro-2H,4H-isoquinoline-1,3-dione | HCID 20384991 | — |
Reaction Steps
2.7 gm of 4,4-dimethyl-7-amino-8-nitro-2H,4H-isoquinoline-1,3-dione were admixed with 50 ml of chloroform and 2.5 ml of triethylamine. Subsequently, 2.2 gm of 2,4-dimethoxybenzoylchloride were added, and the mixture was refluxed for 2 hours. After cooling the solution was evaporated and the precipitate was suction-filtered off and digested with water while heating.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04176184 |
| Source dataset | uspto-grants-1979_11 |
| ORD ID | ord-4daf93f3d00e408d87d772158b269ff5 |
| Source note | uspto-grants-1979_11 |