Barnidipine Hydrochloride → Barnidipine

HRID 47172

Reaction equation

HRID 47172 reaction equation
[CH3:1][C:2]1[NH:7][C:6]([CH3:8])=[C:5]([C:9]([O:11][C@@H:12]2[CH2:16][N:15]([CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:14][CH2:13]2)=[O:10])[C@@H:4]([C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([N+:30]([O-:32])=[O:31])[CH:25]=2)[C:3]=1[C:33]([O:35][CH3:36])=[O:34].Cl>O.CO>[CH3:1][C:2]1[NH:7][C:6]([CH3:8])=[C:5]([C:9]([O:11][C@@H:12]2[CH2:16][N:15]([CH2:17][C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH2:14][CH2:13]2)=[O:10])[C@@H:4]([C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([N+:30]([O-:32])=[O:31])[CH:25]=2)[C:3]=1[C:33]([O:35][CH3:36])=[O:34]

Participants

3

Reactant 1

HCID 443868Barnidipine Hydrochloride

Product 1

HCID 443869Barnidipine

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

Barnidipine hydrochloride, TC-5E and HCO-40 were dissolved in water-methanol (1:9). Separately, PEG20000 and POLYOX303 were mixed. Using a fluidized-bed granulator, the latter mixture was sprayed with the above solution. The granules thus prepared were dried, and after addition of lubricant, the composition was compression-molded to provide tablets each measuring 9.0 mm in diameter and 300 mg (barnidipine HCl content: 15 mg).

Workup

  1. additionSeparately, PEG20000 and POLYOX303 were mixed
  2. customThe granules thus prepared
  3. customwere dried
  4. additionafter addition of lubricant

Sources & evidence

ORD record
ord-bc20141c7e094b3d8c1c83c7c79da1dd
Source dataset
uspto-grants-2004_03
Patent number
US06699503B1

Linked notes

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