2-Amino-6-fluorobenzonitrile → 1-(3-(3-Amino-2-cyanophenoxy)-2,2-dimethylpropyl)-3-(4-methoxybenzyl)urea
Reaction equation
[OH:1][CH2:2][C:3]([CH3:19])([CH3:18])[CH2:4][NH:5][C:6]([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1)=[O:7].[NH2:20][C:21]1[CH:28]=[CH:27][CH:26]=[C:25](F)[C:22]=1[C:23]#[N:24]>>[NH2:20][C:21]1[C:22]([C:23]#[N:24])=[C:25]([CH:26]=[CH:27][CH:28]=1)[O:1][CH2:2][C:3]([CH3:19])([CH3:18])[CH2:4][NH:5][C:6]([NH:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([O:16][CH3:17])=[CH:14][CH:15]=1)=[O:7]Participants
3
Procedure
Prepared as in Example 215b (Method B) from 1-(3-hydroxy-2,2-dimethylpropyl)-3-(4-methoxybenzyl)urea (Example 252c) and 2-amino-6-fluorobenzonitrile in 60% yield. MS 383 (MH+).
Sources & evidence
- ORD record
- ord-2946895bfe8846f1b629eb33f85b9eef
- Source dataset
- uspto-grants-2014_01