5-Chloro-2-ethoxyphenylboronic acid → 2-Chloro-8-(2-ethoxy-5-chloro-phenyl)-[1,2,4]triazolo[1,5-a]pyridine

HRID 472578

Reaction equation

HRID 472578 reaction equation
Br[C:2]1[C:3]2[N:4]([N:8]=[C:9]([Cl:11])[N:10]=2)[CH:5]=[CH:6][CH:7]=1.[CH2:12]([O:14][C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=1B(O)O)[CH3:13]>>[Cl:11][C:9]1[N:10]=[C:3]2[C:2]([C:20]3[CH:19]=[C:18]([Cl:21])[CH:17]=[CH:16][C:15]=3[O:14][CH2:12][CH3:13])=[CH:7][CH:6]=[CH:5][N:4]2[N:8]=1

Participants

3

Reactant 2

HCID 37008365-Chloro-2-ethoxyphenylboronic acidHCID 674813708-Bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyridine

Product 1

HCID 674790412-Chloro-8-(2-ethoxy-5-chloro-phenyl)-[1,2,4]triazolo[1,5-a]pyridine

Procedure

2-Chloro-8-(2-ethoxy-5-chloro-phenyl)-[1,2,4]triazolo[1,5-a]pyridine was prepared from 8-bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyridine and 2-ethoxy-5-chloro-phenylboronic acid in a manner analogous to Example 2c (0.46 g, 66%). MS=322 (MH)+.

Sources & evidence

ORD record
ord-6bcc8ced752c43819c90cd6f145fb5fc
Source dataset
uspto-grants-2014_01
Patent number
US08633173B2

Linked notes

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