5-Chloro-2,4-dimethoxyaniline → (2-{1-[(5-Chloro-2,4-dimethoxy-phenylcarbamoyl)-methyl]-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-ethyl)-carbamic acid tert-butyl ester
Reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][N:11]1[C:20](=[O:21])[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]([CH2:22][C:23](O)=[O:24])[C:12]1=[O:26])=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:27][C:28]1[C:29]([O:37][CH3:38])=[CH:30][C:31]([O:35][CH3:36])=[C:32]([CH:34]=1)[NH2:33]>>[C:1]([O:5][C:6](=[O:7])[NH:8][CH2:9][CH2:10][N:11]1[C:20](=[O:21])[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]([CH2:22][C:23](=[O:24])[NH:33][C:32]2[CH:34]=[C:28]([Cl:27])[C:29]([O:37][CH3:38])=[CH:30][C:31]=2[O:35][CH3:36])[C:12]1=[O:26])([CH3:2])([CH3:4])[CH3:3]Participants
3
Procedure
This compound is made analogously to Example 1-2 by replacing Intermediate A with [3-(2-tert-butoxycarbonylamino-ethyl)-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl]-acetic acid and by replacing cyclopentylamine with 5-chloro-2,4-dimethoxyaniline to afford the title compound. The reaction is carried out in DCM.