1-Chloro-4-((3-chloro-4-methoxybenzyl)amino)-6-phthalazinecarbonitrile → 4-(3-Chloro-4-methoxybenzyl)amino-6-cyano-1-[4-hydroxy-4-(hydroxymethyl)piperidino]phthalazine Hydrochloride

HRID 47337Notes

Reaction equation

HRID 47337 reaction equation
Cl.[OH:2][CH2:3][C:4]1([OH:10])[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1.[Cl:11][C:12]1[C:21]2[C:16](=[CH:17][C:18]([C:22]#[N:23])=[CH:19][CH:20]=2)[C:15]([NH:24][CH2:25][C:26]2[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[C:28]([Cl:34])[CH:27]=2)=[N:14][N:13]=1>>[ClH:11].[Cl:34][C:28]1[CH:27]=[C:26]([CH:31]=[CH:30][C:29]=1[O:32][CH3:33])[CH2:25][NH:24][C:15]1[C:16]2[C:21](=[CH:20][CH:19]=[C:18]([C:22]#[N:23])[CH:17]=2)[C:12]([N:7]2[CH2:8][CH2:9][C:4]([OH:10])([CH2:3][OH:2])[CH2:5][CH2:6]2)=[N:13][N:14]=1

Participants

3

Reactant 2

HCID 104510651-Chloro-4-((3-chloro-4-methoxybenzyl)amino)-6-phthalazinecarbonitrileHCID 227444724-(Hydroxymethyl)-4-piperidinol hydrochloride

Product 1

HCID 183746234-(3-Chloro-4-methoxybenzyl)amino-6-cyano-1-[4-hydroxy-4-(hydroxymethyl)piperidino]phthalazine Hydrochloride

Procedure

The resulting 4-(hydroxymethyl)-4-piperidinol hydrochloride was reacted with 1-chloro-4-(3-chloro-4-methoxybenzyl)amino-6-cyanophthalazine in the same manner as in Example 4 to give the title compound.

Sources & evidence

ORD record
ord-afb6f6debc89409891e542396a69450a
Source dataset
uspto-grants-2004_03
Patent number
US06699870B2

Reaction notes

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