1-(4-Fluorophenyl)-1h-indole-5-carboxylic acid → 4-(1-{[1-(4-Fluorophenyl)-1H-indol-5-yl]carbonyl}azetidin-3-yl)-1-pyrimidin-2-ylpiperazin-2-one

HRID 473596

Reaction equation

HRID 473596 reaction equation
C([O:5][C:6]([N:8]1[CH2:11][CH:10]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[N:23]=[CH:22][CH:21]=[CH:20][N:19]=3)[C:14](=[O:24])[CH2:13]2)[CH2:9]1)=O)(C)(C)C.[F:25][C:26]1[CH:31]=[CH:30][C:29]([N:32]2[C:40]3[C:35](=[CH:36][C:37](C(O)=O)=[CH:38][CH:39]=3)[CH:34]=[CH:33]2)=[CH:28][CH:27]=1>>[F:25][C:26]1[CH:31]=[CH:30][C:29]([N:32]2[C:40]3[C:35](=[CH:36][C:37]([C:6]([N:8]4[CH2:11][CH:10]([N:12]5[CH2:17][CH2:16][N:15]([C:18]6[N:19]=[CH:20][CH:21]=[CH:22][N:23]=6)[C:14](=[O:24])[CH2:13]5)[CH2:9]4)=[O:5])=[CH:38][CH:39]=3)[CH:34]=[CH:33]2)=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 226030711-(4-Fluorophenyl)-1h-indole-5-carboxylic acidHCID 668362493-(3-Oxo-4-pyrimidin-2-yl-piperazin-1-yl)-azetidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 668235464-(1-{[1-(4-Fluorophenyl)-1H-indol-5-yl]carbonyl}azetidin-3-yl)-1-pyrimidin-2-ylpiperazin-2-one

Procedure

Cpd 4 was prepared according to the procedures described in Example 2, Step D, using intermediates 3c and 1-(4-fluoro-phenyl)-1H-indole-5-carboxylic acid 3h as starting materials. MS 471 (M+H+).

Workup

  1. customCpd 4 was prepared

Sources & evidence

ORD record
ord-5eacd61f07dd4dbc975932ebc478116b
Source dataset
uspto-grants-2014_01
Patent number
US08637498B2

Linked notes

Loading…