HCID 131731162, compound → rel-(2R,6S)-2-Methyl-6-(trifluoromethyl)morpholine
Reaction equation
C([N:8]1[CH2:13][C@@H:12]([CH3:14])[O:11][C@H:10]([C:15]([F:18])([F:17])[F:16])[CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[F:18][C:15]([F:16])([F:17])[C@H:10]1[O:11][C@H:12]([CH3:14])[CH2:13][NH:8][CH2:9]1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
N-benzyl-trans-2-trifluoromethyl-6-methylmorpholine [1223452-62-7] (7.5 g, 28.93 mmol) was added to a suspension of Pd/C 10% (1 g) in methanol (150 mL). The reaction mixture was stirred at room temperature under a hydrogen atmosphere until 1 equivalent of hydrogen was absorbed. The catalyst was removed by filtration over diatomaceous earth. The solvent was evaporated, yielding 3.3 g (67%) of Intermediate 30 as an oil that was used without further purification.
Workup
- customwas absorbed
- customThe catalyst was removed by filtration over diatomaceous earth
- customThe solvent was evaporated
Sources & evidence
- ORD record
- ord-01d325a6a63c413dad091ad2bdb671a3
- Source dataset
- uspto-grants-2014_01
- Patent number
- US08637510B2
Reaction notes
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