HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 5,7-dichloro-3-methyl-4-(2,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid Ethyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 3,5-Dichloroaniline | HCID 12281 | — |
| Reactant | 2-Ketobutyrate | HCID 3593277 | — |
| Reactant | Beta-Asarone | HCID 5281758 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 5,7-dichloro-3-methyl-4-(2,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid Ethyl Ester | HCID 10182631 | — |
Reaction Steps
Compound 47 was prepared by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol β-asaron and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06699877B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-b3314ddbf4d24b39acf27f68fdb1c33c |
| Source note | uspto-grants-2004_03 |