HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Ethyl 6,6a,7,11b-tetrahydro-5H-indeno[2,1-c]quinoline-6-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Indene | HCID 7219 | — |
| Reactant | 3,5-Dichloroaniline | HCID 12281 | — |
| Reactant | 2-Ketobutyrate | HCID 3593277 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Ethyl 6,6a,7,11b-tetrahydro-5H-indeno[2,1-c]quinoline-6-carboxylate | HCID 495051 | 89% |
Reaction Steps
Compound 61 was prepared with a yield of 89% by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol indene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06699877B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-25c685d2029c421d87fc7d08ba62101e |
| Source note | uspto-grants-2004_03 |