Glyoxylic Acid → 6,8,9-Trichloro-2,3,3a,4,5,9b-hexahydro-furo[3,2-c]quinoline-4-carboxylic acid

HRID 47415

Reaction equation

HRID 47415 reaction equation

[Cl:1][C:2]1[CH:8]=[C:7]([Cl:9])[C:6]([Cl:10])=[CH:5][C:3]=1[NH2:4].[C:11]([OH:15])(=[O:14])[CH:12]=O.[O:16]1[CH:20]=[CH:19][CH2:18][CH2:17]1>>[Cl:1][C:2]1[C:3]2[NH:4][CH:12]([C:11]([OH:15])=[O:14])[CH:18]3[CH2:19][CH2:20][O:16][CH:17]3[C:5]=2[C:6]([Cl:10])=[C:7]([Cl:9])[CH:8]=1

Participants

4

Reactant 3

HCID 760Glyoxylic Acid

HCID 124872,4,5-Trichloroaniline

HCID 709342,3-Dihydrofuran

Product 1

HCID 99669666,8,9-Trichloro-2,3,3a,4,5,9b-hexahydro-furo[3,2-c]quinoline-4-carboxylic acid

Procedure

Compound 67 was prepared from 2,4,5-trichloroaniline, glyoxylic acid and 2,3-dihydrofuran by the automated process.

Sources & evidence

ORD record: ord-eb3b5948b8064207bc191357b8dc9e1b
Source dataset: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06699877B2

Linked notes

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