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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 47421Generated: October 23, 2026

Ethyl oxoacetate → 6-Sec-butyl-4-(6-chlorobenzo[1,3]dioxol-5-yl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid ethyl ester

https://huagongshe.com/en/reaction/47421

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl oxoacetateHCID 70211—
ReactantBenzenamine, 4-(1-methylpropyl)-HCID 121771—
Reactant5-Chloro-6-vinyl-benzo[1,3]dioxolHCID 12174991—
Product6-Sec-butyl-4-(6-chlorobenzo[1,3]dioxol-5-yl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid ethyl esterHCID 10112564—

Reaction Steps

Compound 77 was prepared from 4-sec-butylaniline, glyoxylic acid ethyl ester and 5-chloro-6-vinyl-benzo[1,3]dioxol by the automated process.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06699877B2
Source datasetuspto-grants-2004_03
ORD IDord-4fac8855370d4f90a74b316a3e19cc3c
Source noteuspto-grants-2004_03