(1H-indol-4-yl)methanamine → HCID 178420481, compound

Reaction equation

Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:13]=[C:12]([O:14][CH2:15][CH:16]3[CH2:18][CH2:17]3)[NH:11][N:10]=2)[CH:5]=[CH:4][N:3]=1.[NH:19]1[C:27]2[C:22](=[C:23]([CH2:28][NH2:29])[CH:24]=[CH:25][CH:26]=2)[CH:21]=[CH:20]1>>[NH:19]1[C:27]2[C:22](=[C:23]([CH2:28][NH:29][C:2]3[N:7]=[C:6]([NH:8][C:9]4[CH:13]=[C:12]([O:14][CH2:15][CH:16]5[CH2:18][CH2:17]5)[NH:11][N:10]=4)[CH:5]=[CH:4][N:3]=3)[CH:24]=[CH:25][CH:26]=2)[CH:21]=[CH:20]1

Participants

Reactant 2

HCID 280302(1H-indol-4-yl)methanamine

HCID 178478347HCID 178478347, compound

Product 1

HCID 178420481HCID 178420481, compound

Procedure

N2-((1H-indol-4-yl)methyl)-N4(5-(cyclopropylmethoxy)-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (I-42) was prepared analogously except 77 was replaced with (2-chloro-pyrimidin-4-yl)-(5-cyclopropylmethoxy-1H-pyrazol-3-yl)-amine and (1H-indol-4-yl)methanamine was replaced with 116.

Sources & evidence

ORD record: ord-80e86eed27a243878ffccf4f9499323b
Source dataset: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08637537B2

Reaction notes

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