Benzyl Alcohol → HCID 19838067, compound

Reaction equation

[OH:1][CH:2]1[NH:6][C:5](=[O:7])[CH:4]=[CH:3]1.[CH2:8](O)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[CH2:8]([O:1][CH:2]1[NH:6][C:5](=[O:7])[CH:4]=[CH:3]1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

Reactant 2

HCID 244Benzyl Alcohol

HCID 353549(R)-Dihydromaleimide

Product 1

HCID 19838067HCID 19838067, compound

Conditions

Temperature: 60 °C

Procedure

A mixture of 8 g of 1,5-dihydro-5-hydroxy-2H-pyrrol-2-one in 130 cm3 of benzyl alcohol and 4 g of Amberlite IR 120 H is heated for 3 hours at 60° C. The benzyl alcohol is distilled off at 65° C. under 0.3 mbar. then is drawn off under azeotropic form first with water and then with benzene. 13.6 g of the expected product is obtained, which is unstable on distilling.

Workup

distillationThe benzyl alcohol is distilled off at 65° C. under 0.3 mbar

Sources & evidence

ORD record: ord-ad2103d7329d4a8f85a37c994e45dd09
Source dataset: uspto-grants-1989_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04885307

Reaction notes

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