Potassium Hydroxide → HCID 19836535, compound

HRID 476825

Reaction equation

HRID 476825 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15](=[O:17])[CH3:16])=[CH:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[OH:8].C1(C)C=CC(S(O[CH:28]([CH3:35])[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])(=O)=O)=CC=1.[OH-].[K+]>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15](=[O:17])[CH3:16])=[CH:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH:28]([CH3:35])[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 3912199p-Toluenesulfonic acid 1-methylheptyl esterHCID 14474361HCID 14474361, compound

Product 1

HCID 19836535HCID 19836535, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The above 3'-bromo-4'-hydroxy-4-acetylbiphenyl (200 g) was treated with 1.2 times equivalents of R 1-methylheptyl p-toluenesulfonate and potassium hydroxide in 97% ethanol (1 l) for 6 hours under reflux. The reaction mixture was worked up in a usual way to obtain crude oily 3'-bromo-4'-(1-methylheptyloxy)-4-acetylbiphenyl (163 g).

Workup

  1. temperatureunder reflux

Sources & evidence

ORD record
ord-a1bd88eaf8ec4544ad9ec66057274992
Source dataset
uspto-grants-1989_12
Patent number
US04886622

Linked notes

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