Sodium Hydroxide → disodium 2-[[N-(chloroacetyl)glycyl]amino]malonate

HRID 477203Notes

Reaction equation

HRID 477203 reaction equation
[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]([NH:9][CH:10]([C:16]([O:18]CC)=[O:17])[C:11]([O:13]CC)=[O:12])=[O:8])=[O:4].[OH-].[Na+:22]>>[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]([NH:9][CH:10]([C:16]([O-:18])=[O:17])[C:11]([O-:13])=[O:12])=[O:8])=[O:4].[Na+:22].[Na+:22]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 15053734Diethyl 2-[[N-(chloroacetyl)glycyl]amino]malonate

Product 1

HCID 19837444disodium 2-[[N-(chloroacetyl)glycyl]amino]malonate

Procedure

Diethyl 2-[[N-(chloroacetyl)glycyl]amino]malonate (0.68 g) is added to 1N aqueous sodium hydroxide (4.7 ml), and the mixture is reacted at room temperature for 10 hours, and the reaction mixture is concentrated. The residue is washed with methanol to give disodium 2-[[N-(chloroacetyl)glycyl]amino]malonate (0.65 g).

Workup

  1. customthe mixture is reacted at room temperature for 10 hours
  2. concentrationthe reaction mixture is concentrated
  3. washThe residue is washed with methanol

Sources & evidence

ORD record
ord-952031986fac4984b79482a3558ef6ef
Source dataset
uspto-grants-1989_12
Patent number
US04886894

Reaction notes

Loading…