tert-Butyl isothiocyanate → N-(tert-butyl)-N'-[(1R)-2-hydroxy-1-(3-carboxybenzyl)ethyl]thiourea

Participants

Reaction Conditions

Reaction Steps

The process is performed as in Example 2, starting with 1.82 g of (2R)-2-amino-3-(3-carboxyphenyl)-1-propanol hydrochloride in 20 cm3 of ethanol, 4.2 cm3 of triethylamine and 1.7 cm3 of tert-butyl isothiocyanate. After heating for 21 hours at a temperature in the region of 60° C. and an identical work-up, 2.31 g of N-(tert-butyl)-N′-[(1R)-2-hydroxy-1-(3-carboxybenzyl)ethyl]thiourea are obtained in the form of a light brown foam. (Rf=0.33 in a 12/6/1 by volume mixture of chloroform/methanol/aqueous ammonia, on a Merck 60F254R silica plate).

Provenance & Evidence