Ammonia → 1-(2-Amino-3,5-dinitrophenyl)-2-propanol

HRID 477603

Reaction equation

HRID 477603 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([N+:14]([O-:16])=[O:15])[C:7]2[O:11][CH:10]([CH3:12])[CH2:9][C:8]=2[CH:13]=1)([O-:3])=[O:2].[NH3:17].COCCO>O>[NH2:17][C:7]1[C:6]([N+:14]([O-:16])=[O:15])=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:13][C:8]=1[CH2:9][CH:10]([OH:11])[CH3:12]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 80192-MethoxyethanolHCID 198363332-Methyl-5,7-dinitro-2,3-dihydro-1-benzofuran

Product 1

HCID 198363271-(2-Amino-3,5-dinitrophenyl)-2-propanol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
70 °C

Procedure

0.39 Mole (88 g) of 2,3-dihydro-5,7-dinitro-2-methylbenzofuran, prepared according to J.A.C.S. 80, p. 4711-4714 (1958), is suspended in 1.1 l of 20% strength ammonia solution and 600 ml of Methyl Cellosolve. After 18 hours' heating at 70° C., the reaction mixture is cooled. The precipitate formed is drained and, after being made into a paste in water until neutral and then dried under vacuum, is recrystallized from 170 ml of dioxane. After being dried under vacuum, 0.30 mole (72 g) of the expected product is obtained; it melts at 177° C.

Workup

  1. temperaturethe reaction mixture is cooled
  2. customThe precipitate formed
  3. customthen dried under vacuum
  4. customis recrystallized from 170 ml of dioxane
  5. customAfter being dried under vacuum

Sources & evidence

ORD record
ord-ff0b4bb999704748b01af5ebc755d6b5
Source dataset
uspto-grants-1989_12
Patent number
US04888445

Linked notes

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