HCID 178419031, compound → HCID 178418735, compound

HRID 478185

Reaction equation

HRID 478185 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([NH:15][C:16]([NH2:18])=[NH:17])[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>CCO.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([NH:15][C:16]([NH2:18])=[NH:17])[CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 1

HCID 178419031HCID 178419031, compound

Product 1

HCID 178418735HCID 178418735, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of N-(3-benzyloxy-phenyl)guanidine (5.0 g, 20.6 mmol) in EtOH (150 mL) was added palladium on carbon (10%, wet, 50% water, 0.5 g)). The mixture was stirred under hydrogen atmosphere overnight. The reaction was filtered through a plug of celite and the filtrate concentrated in vacuo. with toluene azeotroping to affored the desired material (2.83 g, 91%). 1H NMR (MeOH-d4) δ6.4-7 (m, 4H)

Workup

  1. filtrationThe reaction was filtered through a plug of celite
  2. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-d6c02952b6ab4954bab6ec20e5471e3f
Source dataset
uspto-grants-2003_11
Patent number
US06642227B2

Linked notes

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