2-Cyano-3-cyclohexyl-3-oxo-propionic acid ethyl ester → 3-Cyclohexyl-3-oxopropanenitrile
Reaction equation
C(OC(=O)[CH:5]([C:14]#[N:15])[C:6]([CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)=[O:7])C>CS(C)=O.O>[CH:8]1([C:6](=[O:7])[CH2:5][C:14]#[N:15])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 2-cyano-3-cyclohexyl-3-oxo-propionic acid ethyl ester in DMSO:water (10:1) was stirred at 120° C. for 2 hours. The reaction mixture was partitioned between ether and 1N HCl, the organic phase was dried with MgSO4 and the solvent removed under reduced pressure.
Workup
- customThe reaction mixture was partitioned between ether and 1N HCl
- dry with materialthe organic phase was dried with MgSO4
- customthe solvent removed under reduced pressure
Sources & evidence
- ORD record
- ord-77dd8144fad54d2a9f71c7b13b36520b
- Source dataset
- uspto-grants-2003_11
- Patent number
- US06642227B2
Reaction notes
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