HCID 53406803, compound → Methyl 4-(piperazin-1-yl)benzoate

HRID 478635

Reaction equation

HRID 478635 reaction equation
[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13](CC3C=CC=CC=3)[CH2:12][CH2:11]2)=[CH:6][CH:5]=1.[H][H]>CO.[Pd].C>[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:8][CH:9]=1

Participants

5

Reactant 2

HCID 53406803HCID 53406803, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 15429161Methyl 4-(piperazin-1-yl)benzoate

Reagents, catalysts & solvents 2

HCID 14818447PalladiumcarbonCatalystHCID 887MethanolSolvent

Procedure

4-(4-Benzyl-piperazin-1-yl)-benzoic acid methyl ester (19.4 mmol) is dissolved in methanol (150 ml) and Pd/charcoal is added (0.6 g). The mixture is stirred in a hydrogen atmosphere until consumption has ceased. The catalyst is filtered off and the filtrate evaporated. The residue is suspended in diethylether/pentane and the solid filtered of and dried (vacuum). A powder with mp. 95-97° C. is obtained.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe filtrate evaporated
  3. filtrationthe solid filtered of and
  4. customdried (vacuum)
  5. customA powder with mp. 95-97° C. is obtained

Sources & evidence

ORD record
ord-305fc93190cc47c78bc1b9788ef9a944
Source dataset
uspto-grants-2003_11
Patent number
US06642239B2

Linked notes

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