(3-Methoxyphenyl)acetic acid → 2-[(3-Methoxyphenyl)acetamido]butyric acid isobutyl ester

HRID 478792

Reaction equation

HRID 478792 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][C:10]([OH:12])=O)[CH:6]=[CH:7][CH:8]=1.[NH2:13][CH:14]([CH2:22][CH3:23])[C:15]([O:17][CH2:18][CH:19]([CH3:21])[CH3:20])=[O:16]>>[CH2:18]([O:17][C:15](=[O:16])[CH:14]([NH:13][C:10](=[O:12])[CH2:9][C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=1)[CH2:22][CH3:23])[CH:19]([CH3:20])[CH3:21]

Participants

3

Reactant 2

HCID 15719(3-Methoxyphenyl)acetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 538243972-[(3-Methoxyphenyl)acetamido]butyric acid isobutyl ester

Procedure

Following General Procedure I above and using 3-methoxyphenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared frollowing General Procedure J above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-c6f1e3bf153a416285da33713b3e3a87
Source dataset
uspto-grants-2003_11
Patent number
US06642261B2

Linked notes

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